Hotel Midi-Zuid is 350 m from Brussels-South Railway Station and the Eurostar terminal, only a 15-minute walk from Brussels' Grand Place. It is next to Lemonnier Metro Station and benefits from a 24-hour front desk and free WiFi.

Cable TV, a minibar as well as tea and coffee facilities come as standard rooms at Hotel Midi-Zuid. They also include a work desk and a bathroom with a shower. Some rooms come with a seating area with a sofa.

The Manneken Pis Statue is less than a 15-minute walk away. Hotel Midi-Zuid is a 10-minute walk from the National Resistance Museum. Le Musée bruxellois de la Gueuze is 500 m from the hotel.